Matrix Assisted Laser Desorption/Ionization Mass Spectrometry (MALDI-MS) is a cornerstone in biomolecular analysis, offering precise identification of pathogens through unique mass spectral signatures. Yet, its reliance on labor-intensive sample preparation and multi-shot spectral averaging restricts its use to laboratory settings, rendering it impractical for real-time environmental monitoring. These limitations are especially pronounced in emerging aerosol MALDI-MS systems, where autonomous sampling generates noisy spectra for unknown aerosol analytes, requiring single-shot detection for effective analysis. Addressing these challenges, we propose the Mass Spectral Dictionary-Guided Transformer (MS-DGFormer): a data-driven framework that redefines spectral analysis by directly processing raw, minimally prepared mass spectral data. MS-DGFormer leverages a transformer architecture, designed to capture the long-range dependencies inherent in these time-series spectra. To enhance feature extraction, we introduce a novel dictionary encoder that integrates denoised spectral information derived from Singular Value Decomposition (SVD), enabling the model to discern critical biomolecular patterns from single-shot spectra with robust performance. This innovation provides a system to achieve superior pathogen identification from aerosol samples, facilitating autonomous, real-time analysis in field conditions. By eliminating the need for extensive preprocessing, our method unlocks the potential for portable, deployable MALDI-MS platforms, revolutionizing environmental pathogen detection and rapid response to biological threats.

For example, in the Pandemic Response Challenge experiment, the context consisted of data about the geographic region for which the predictions were made, e.g., historical data of COVID-19 cases and intervention policies; actions were future schedules of intervention policies for the region; and outcomes were predicted future cases of COVID-19 along with the stringency

The law draws a sharp distinction between objects and persons, and between two kinds of persons, the ''fictional'' kind (i.e. corporations), and the ''non-fictional'' kind (individual or ''natural'' persons). This paper will assess whether we maximize overall long-term legal coherence by (A) maintaining an object classification for all future AI systems, (B) creating fictional legal persons associated with suitably advanced, individuated AI systems (giving these fictional legal persons derogable rights and duties associated with certified groups of existing persons, potentially including free speech, contract rights, and standing to sue ''on behalf of'' the AI system), or (C) recognizing non-fictional legal personhood through legal identity for suitably advanced, individuated AI systems (recognizing them as entities meriting legal standing with non-derogable rights which for the human case include life, due process, habeas corpus, freedom from slavery, and freedom of conscience). We will clarify the meaning and implications of each option along the way, considering liability, copyright, family law, fundamental rights, civil rights, citizenship, and AI safety regulation. We will tentatively find that the non-fictional personhood approach may be best from a coherence perspective, for at least some advanced AI systems. An object approach may prove untenable for sufficiently humanoid advanced systems, though we suggest that it is adequate for currently existing systems as of 2025. While fictional personhood would resolve some coherence issues for future systems, it would create others and provide solutions that are neither durable nor fit for purpose. Finally, our review will suggest that ''hybrid'' approaches are likely to fail and lead to further incoherence: the choice between object, fictional person and non-fictional person is unavoidable.

For example, in the Pandemic Response Challenge experiment, the context consisted of data about the geographic region for which the predictions were made, e.g., historical data of COVID-19 cases and intervention policies; actions were future schedules of intervention policies for the region; and outcomes were predicted future cases of COVID-19 along with the stringency

As frontier artificial intelligence (AI) models rapidly advance, benchmarks are integral to comparing different models and measuring their progress in different task-specific domains. However, there is a lack of guidance on when and how benchmarks should be deprecated once they cease to effectively perform their purpose. This risks benchmark scores over-valuing model capabilities, or worse, obscuring capabilities and safety-washing. Based on a review of benchmarking practices, we propose criteria to decide when to fully or partially deprecate benchmarks, and a framework for deprecating benchmarks. Our work aims to advance the state of benchmarking towards rigorous and quality evaluations, especially for frontier models, and our recommendations are aimed to benefit benchmark developers, benchmark users, AI governance actors (across governments, academia, and industry panels), and policy makers.

Understanding how policy language evolves over time is critical for assessing global responses to complex challenges such as climate change. Temporal analysis helps stakeholders, including policymakers and researchers, to evaluate past priorities, identify emerging themes, design governance strategies, and develop mitigation measures. Traditional approaches, such as manual thematic coding, are time-consuming and limited in capturing the complex, interconnected nature of global policy discourse. With the increasing relevance of unsupervised machine learning, these limitations can be addressed, particularly under high-volume, complex, and high-dimensional data conditions. In this work, we explore a novel approach that applies the dynamic embedded topic model (DETM) to analyze the evolution of global climate policy discourse. A probabilistic model designed to capture the temporal dynamics of topics over time. We collected a corpus of United Nations Framework Convention on Climate Change (UNFCCC) policy decisions from 1995 to 2023, excluding 2020 due to the postponement of COP26 as a result of the COVID-19 pandemic. The model reveals shifts from early emphases on greenhouse gases and international conventions to recent focuses on implementation, technical collaboration, capacity building, finance, and global agreements. Section 3 presents the modeling pipeline, including preprocessing, model training, and visualization of temporal word distributions. Our results show that DETM is a scalable and effective tool for analyzing the evolution of global policy discourse. Section 4 discusses the implications of these findings and we concluded with future directions and refinements to extend this approach to other policy domains.

Climate policy scenario generation and evaluation have traditionally relied on integrated assessment models (IAMs) and expert-driven qualitative analysis. These methods enable stakeholders, such as policymakers and researchers, to anticipate impacts, plan governance strategies, and develop mitigation measures. However, traditional methods are often time-intensive, reliant on simple extrapolations of past trends, and limited in capturing the complex and interconnected nature of energy and climate issues. With the advent of artificial intelligence (AI), particularly generative AI models trained on vast datasets, these limitations can be addressed, ensuring robustness even under limited data conditions. In this work, we explore the novel method that employs generative AI, specifically large language models (LLMs), to simulate climate policy scenarios for Sub-Saharan Africa. These scenarios focus on energy transition themes derived from the historical United Nations Climate Change Conference (COP) documents. By leveraging generative models, the project aims to create plausible and diverse policy scenarios that align with regional climate goals and energy challenges. Given limited access to human evaluators, automated techniques were employed for scenario evaluation. We generated policy scenarios using the llama3.2-3B model. Of the 34 generated responses, 30 (88%) passed expert validation, accurately reflecting the intended impacts provided in the corresponding prompts. We compared these validated responses against assessments from a human climate expert and two additional LLMs (gemma2-2B and mistral-7B). Our structured, embedding-based evaluation framework shows that generative AI effectively generate scenarios that are coherent, relevant, plausible, and diverse. This approach offers a transformative tool for climate policy planning in data-constrained regions.

Large Language Models (LLMs) have demonstrated remarkable capabilities in natural language processing tasks. Still, they are prone to generating hallucinations--factually incorrect or fabricated content that can undermine their reliability, especially in high-stakes domains such as healthcare and legal advisory. In response to this challenge, we propose Delta, a novel inference-time approach that leverages contrastive decoding to mitigate hallucinations without requiring model retraining or additional training data. Delta works by randomly masking portions of the input prompt, then contrasting the original and masked output distribution generated by the model, effectively mitigating hallucinations through inferenceonly computations. Delta was evaluated on context-rich QA benchmarks like SQuAD v1.1 and v2, achieving around 3 and 6 percentage points of improvement, respectively. It also showed gains of 7 and 2 percentage points on TriviaQA and Natural Question under-sampling decoding. Delta improved SQuAD v2's noanswer exact match by over ten percentage points.